[Immuno-hematological indicator levels in patients with Meniere disease and their associations with clinical characteristics].

Objective: To investigate the levels of immuno-hematological parameters in patients with Meniere disease (MD) and their associations with clinical features. Methods: The clinical data from MD patients collected at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology between May 2011 and April 2022 were retrospectively analyzed. The parameters were as follows: autoantibodies, humoral immunity markers, lymphocyte subsets, and complete blood counts. Levels of abovementioned parameters were compared between patients with disease duration of≤12 months and>12 months, and among those at audiological stages Ⅰ~Ⅳ. Results: A total of 113 MD patients aged (52.3±12.8) years were included, with 37 males (32.7%) and 76 females (67.3%). There were 52.2% of patients (59/113) who had a disease duration of>12 months. Audiological staging included 16 stageⅠ, 20 stage Ⅱ, 61 stage Ⅲ, and 16 stage Ⅳ cases. The overall rate of antinuclear antibody (ANA) positivity was 20.5% (23/112), with rates of 25.9% (15/58) and 14.8% (8/54) in patients having a disease duration of>12 months and≤12 months, respectively (χ2=1.835, P=0.176). By stage, ANA positivity was 13.3% (2/15) in stage Ⅰ, 30.0% (6/20) in stage Ⅱ, 19.7% (12/61) in stage Ⅲ, and 18.8% (3/16) in stage Ⅳ(χ2=1.708, P=0.635). Among humoral markers, 5.5% (4/73) of patients had elevated IgG and 30.1% (22/73) had reduced complement C3, with no significant differences by duration or stage (all P>0.05). Abnormal rates for lymphocyte subsets were26.4% (23/87) in total T cells, 33.3% (29/87) in CD4+T cells, 29.9% (26/87) in CD8+T cells, 21.8% (19/87) in B cells, and 27.6% (24/87) in natural killer (NK) cells, with no significant differences by duration or stage (all P>0.05). Conclusion: MD patients exhibit certain immuno-hematological abnormalities, which do not directly correlate with disease duration or the degree of hearing impairment.