Peptides · 2003
Effects of adrenomedullin on the contraction of gastric arteries during reserpine-induced gastric ulcer.
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Salomone Salvatore, Caruso Antonina, Cutuli Vincenza Maria, Mangano Nunzio Guido, Prato Agata, Amico-Roxas Matilde, Bianchi Alfredo, Clementi Giuseppe
Аннотация
Adrenomedullin (100 ng/kg, s.c.) prevents reserpine-induced damage of gastric mucosa. In the model of in vitro gastric arteries from reserpine-treated rats, adrenomedullin pre-treatment resulted in a decrease of the vasoconstriction in response to 5-hydroxytryptamine. In contrast, adrenomedullin pre-treatment of rat with intact gastric mucosa did not affect the vasoconstriction to 5-hydroxytryptamine. In the presence of the NOS inhibitor N(G)-nitro-L-arginine, the responsiveness to 5-hydroxytryptamine in gastric arteries from rats treated with reserpine + adrenomedullin was enhanced to the same level of rats treated with reserpine alone. The anti-ulcer effect of adrenomedullin could therefore be related, at least in part, to an increase of blood flow at the gastric mucosa, by a mechanism involving nitric oxide.