[Humoral pressor substances in a constellation of rheumatic heart defects with systemic arterial hypertension].

A study of the functional state of the pressor sympathetic-adrenal and renin-angiotensin-aldosterone systems in 112 patients with rheumatic heart disease associated with systemic arterial hypertension indicates that changes in the activity of pressor humoral systems depended on the pathogenetic form of arterial hypertension, phase of arterial hypertension and severity of hemodynamic disorders. These was a close correlation between the excretion of noradrenalin, plasma renin activity and aldosteron concentration indicating that these two humoral systems change in the same direction and confirm their undoubted participation in the pathogenesis of arterial hypertension in rheumatic heart disease.