Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit · 2004
Quinine therapy in severe Plasmodium falciparum malaria during pregnancy in Sudan.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Adam I, Mirghani O A, Saed O K, Ahmed S M, Mohamadani A A, Ahmed H M, Mackenzie C D, Homeida M M A, Elbashir M I
Аннотация
A prospective study was carried out in an area of unstable malaria transmission in central Sudan to determine the efficacy and toxicity of quinine in pregnancy. Thirty-three pregnant women with severe Plasmodium falciparum malaria at mean 28.8 weeks gestational age were treated with quinine for 7 days. The mean body temperature on presentation for 3 patients who delivered prematurely was significantly higher than for those who delivered at term (39.2 +/- 0.7 degrees C versus 38.7 +/- 1.3 degrees C). There were no significant difference between the 2 groups in other clinical or biochemical parameters. There were no clinically detectable congenital malformations and no auditory, visual or other neurological deficits in the babies at birth or 6 months later. Quinine may be safe in the treatment of severe falciparum malaria during pregnancy.
Предметные рубрики MeSH
Administration, OralAdultAntimalarialsBody TemperatureDrug Administration ScheduleFemaleGestational AgeHumansInfusions, IntravenousMalaria, FalciparumPregnancyPregnancy Complications, ParasiticPregnancy OutcomePrenatal CareProspective StudiesQuinineSafetySeasonsSeverity of Illness IndexSudanTreatment Outcome