Медицинская библиотека · Movement disorders clinical practice · 2024

Family History in Parkinson's Disease: A National Cross-Sectional Study.

Arienti Federica, Casazza Giovanni, Franco Giulia, Lazzeri Giulia, Monfrini Edoardo, Di Maio Alessandro, Erro Roberto, Barone Paolo, Tamma Filippo, Caputo Elena, Volontè Maria Antonietta, Cacciaguerra Laura, Pilotto Andrea, Padovani Alessandro, Comi Cristoforo, Magistrelli Luca, Valzania Franco, Cavallieri Francesco, Avanzino Laura, Marchese Roberta, Sensi Mariachiara, Carroli Giorgia, Eleopra Roberto, Cilia Roberto, Spagnolo Francesca, Tessitore Alessandro, De Micco Rosa, Ceravolo Roberto, Palermo Giovanni, Malaguti Maria Chiara, Lopiano Leonardo, Tocco Pierluigi, Sorbera Chiara, Tinazzi Michele, Ciammola Andrea, Ottaviani Donatella, Valente Enza Maria, Albanese Alberto, Blandini Fabio, Canesi Margherita, Antonini Angelo, Carecchio Miryam, Fetoni Vincenza, Colosimo Carlo, Volpe Daniele, Tambasco Nicola, Cossu Giovanni, Zappia Mario, Italian Study Group on Family History in PD, Di Fonzo Alessio

СтатьяМногоцентровое исследованиеПеревод пока не подготовлен

Аннотация

BACKGROUND

Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.

OBJECTIVES

We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).

METHODS

A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.

RESULTS

Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.

CONCLUSIONS

fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.

Для цитирования: Arienti Federica, Casazza Giovanni, Franco Giulia, Lazzeri Giulia, Monfrini Edoardo, Di Maio Alessandro, Erro Roberto, Barone Paolo, Tamma Filippo, Caputo Elena, Volontè Maria Antonietta, Cacciaguerra Laura, Pilotto Andrea, Padovani Alessandro, Comi Cristoforo, Magistrelli Luca, Valzania Franco, Cavallieri Francesco, Avanzino Laura, Marchese Roberta, Sensi Mariachiara, Carroli Giorgia, Eleopra Roberto, Cilia Roberto, Spagnolo Francesca, Tessitore Alessandro, De Micco Rosa, Ceravolo Roberto, Palermo Giovanni, Malaguti Maria Chiara, Lopiano Leonardo, Tocco Pierluigi, Sorbera Chiara, Tinazzi Michele, Ciammola Andrea, Ottaviani Donatella, Valente Enza Maria, Albanese Alberto, Blandini Fabio, Canesi Margherita, Antonini Angelo, Carecchio Miryam, Fetoni Vincenza, Colosimo Carlo, Volpe Daniele, Tambasco Nicola, Cossu Giovanni, Zappia Mario, Italian Study Group on Family History in PD, Di Fonzo Alessio. Family History in Parkinson's Disease: A National Cross-Sectional Study.. Movement disorders clinical practice. 2024. DOI: 10.1002/mdc3.14206.

Предметные рубрики MeSH

Humans Parkinson Disease Cross-Sectional Studies Male Female Aged Middle Aged Italy Age of Onset Risk Factors Genetic Predisposition to Disease Prevalence

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