The Canadian veterinary journal = La revue veterinaire canadienne · 2021
Recurrence analysis of intraoperative acridine orange-photodynamic therapy for dogs with intranasal tumors.
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Maruo Takuya, Fukuyama Yasuhiro, Nishiyama Yuta, Nemoto Yuki, Kanai Eiichi, Kawarai Shinpei, Kayanuma Hideki, Orito Kensuke
Аннотация
Intraoperative acridine orange-photodynamic therapy (AO-PDT) and cribriform plate irradiation are used to treat canine intranasal tumors. The purpose of this study was to evaluate the effects of AO-PDT on intranasal tumors and the recurrence rate of tumors after this treatment. Treatments with AO-PDT were performed on 38 dogs through a narrow window of the dorsal nasal cavity. The median progression-free interval was 12 mo and recurrence was detected in 21 dogs. Based on computed tomography, recurrence in 16 dogs was biased to the following areas: lateral (n = 10), medial (n = 2), ventral (n = 0), rostral (n = 0), and caudal (n = 8). Side effects were mild and included subcutaneous emphysema and rhinitis. The median survival time was 24 mo. Although AO-PDT with cribriform irradiation is an effective treatment for intranasal tumors, AO-PDT techniques should be improved to treat the nasal cavity more uniformly and thoroughly.