Differences in life expectancy between men and women after aortic valve replacement.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hernandez-Vaquero Daniel, Rodriguez-Caulo Emiliano, Vigil-Escalera Carlota, Blanco-Herrera Oscar, Berastegui Elisabet, Arias-Dachary Javier, Souaf Souhayla, Parody Gertrudis, Laguna Gregorio, Adsuar Alejandro, Castellá Manel, Valderrama José F, Pulitani Ivana, Cánovas Sergio, Ferreiro Andrea, García-Valentín Antonio, Carnero Manuel, Pareja Pilar, Corrales José A, Blázquez José A, Macías Diego, Fletcher-Sanfeliu Delfina, Martínez Daniel, Martín Elio, Martín Miren, Margarit Juan, Hernández-Estefanía Rafael, Monguió Emilio, Otero Juan, Silva Jacobo
Аннотация
METHODS: All patients between 50 and 65 years of age who underwent isolated aortic valve replacement in 27 Spanish centres during an 18-year period were included. We compared observed and expected survival at 15 years of follow-up and estimated the cumulative incidence of death from a competing risks point of view. We stratified by sex and analysed if being a woman was an independent risk factor for death.
RESULTS: For men, the observed survival at 10 and 15 years of follow-up was 85% [95% confidence interval (CI) 83.6%-86.4%] and 72.3% (95% CI 69.7%-74.7%), respectively whereas the expected survival was 88.1% and 78.8%. For women, the observed survival at 10 and 15 years was 85% (95% CI 82.8%-86.9%) and 73% (95% CI 69.1%-76.4%), whereas the expected survival was 94.6% and 89.4%. At 15 years of follow-up, the cumulative incidence of death due to the disease in men and women was 8.2% and 16.7%, respectively. In addition, being a woman was an independent risk factor for death (hazard ratio = 1.23 (95% CI 1.02-1.48; P = 0.03).
CONCLUSIONS: After the aortic valve replacement, men and women do not have their life expectancy restored, but this loss is much higher in women than in men. In addition, being a woman is a risk factor for long-term death. Reasons for these findings are unknown and must be investigated.