The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2011
Microstructural alteration of the anterior cingulum is associated with apathy in Alzheimer disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Kim Jee Wook, Lee Dong Young, Choo Il Han, Seo Eun Hyun, Kim Shin Gyeom, Park Shin Young, Woo Jong Inn
Аннотация
OBJECTIVES: To identify regional alterations of white matter integrity associated with apathy in Alzheimer disease (AD).
DESIGN: Cross-sectional study.
SETTING: University Dementia Clinic.
PARTICIPANTS: Fifty-one very mild or mild probable AD subjects.
INTERVENTION: Volumetric magnetic resonance imaging with diffusion tensor imaging.
MEASUREMENTS: Volume of interest analyses were performed to compare regional fractional anisotropy (FA) between apathy and apathy-free group, and to test linear relationship between regional FA and apathy severity. Apathy was assessed by the Neuropsychiatric Inventory.
RESULTS: Apathy group showed significantly lower FA values than apathy-free group in the left anterior cingulum (A-C), regardless of concomitant depression and psychotropic medications. Left A-C FA values also had significant linear relationship with apathy-composite scores as a measure of apathy severity, even after controlling gray matter density of the ipsilateral anterior cingulate cortex.
CONCLUSIONS: Our findings support that communication failure between the anterior cingulate cortex and other brain structures via the A-C contributes to the development and aggravation of apathy in AD, additionally supporting the general notion of disconnection syndrome for clinical manifestation of AD.
DESIGN: Cross-sectional study.
SETTING: University Dementia Clinic.
PARTICIPANTS: Fifty-one very mild or mild probable AD subjects.
INTERVENTION: Volumetric magnetic resonance imaging with diffusion tensor imaging.
MEASUREMENTS: Volume of interest analyses were performed to compare regional fractional anisotropy (FA) between apathy and apathy-free group, and to test linear relationship between regional FA and apathy severity. Apathy was assessed by the Neuropsychiatric Inventory.
RESULTS: Apathy group showed significantly lower FA values than apathy-free group in the left anterior cingulum (A-C), regardless of concomitant depression and psychotropic medications. Left A-C FA values also had significant linear relationship with apathy-composite scores as a measure of apathy severity, even after controlling gray matter density of the ipsilateral anterior cingulate cortex.
CONCLUSIONS: Our findings support that communication failure between the anterior cingulate cortex and other brain structures via the A-C contributes to the development and aggravation of apathy in AD, additionally supporting the general notion of disconnection syndrome for clinical manifestation of AD.