Journal of clinical periodontology · 2025
Efficacy of Injectable Bone Fillers for Alveolar Ridge Preservation: A Histomorphometrical Analysis.
СтатьяСравнительное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Schwarz Frank, Ramanauskaite Ausra, Obreja Karina, Lorenz Jonas, Sader Robert, Parvini Puria
Аннотация
AIM: To assess the efficacy of injectable bone fillers for alveolar ridge preservation (ARP).
MATERIALS AND METHODS: The mandibular premolars (P2, P3, P4) were bilaterally assigned to ARP in a total of n = 9 beagle dogs. Each P was decapitated and hemisected under preservation of the mesial (i.e., devitalization and filling with calcium hydroxide) and removal of the distal root. The resulting 6 extraction sockets were randomly allocated to a total of four injectable test materials (i.e., bovine bone particles + porcine collagen, lyophilized materials reconstituted with either blood or saline [T1, T2, T4]; or ready-to-use wet material [T3]) and one control material (collagenated bovine bone mineral) (C) as well as one negative control group (N). Primary wound closure was ensured in all test and C groups. At 12 weeks, dissected blocks were prepared for histomorphometrical analyses. Buccal bone height (BBH) was defined as a primary outcome. Lingual bone height (LBH), buccal and lingual bone wall width (BBW and LBW 1, 3 and 5 mm infracrestally), surface area of bone and particles, fibrous tissues, and bone marrows were defined as secondary outcomes. Between-group comparisons were assessed using ANOVA and Mann-Whitney tests.
RESULTS: After 12 weeks, all groups were associated with similar BBH values (BBH: 14.1, 14.0, 13.7, 13.8, 14.3 and 114.2 mm in the T1, T2, T3, T4, C and N groups, respectively; p > 0.05 for all between-group comparisons). The BBW and LBW measurements were comparable among the groups. ARP sites showed a trend towards higher area measurements of bone and particle surfaces compared with the N group (11.5, 11.6, 13.1, 12.5, 9.1 mm2 in T1, T2, T3, T4, C and N groups, respectively). C, T1, T2, T3 and T4 particles were associated with a similar marked grade of osteoconduction and osteointegration within the former extraction socket area.
CONCLUSIONS: Within its limitations, the present study has pointed to the similar efficacy of injectable bone fillers for ARP compared with the particulated bone substitute and negative control.
MATERIALS AND METHODS: The mandibular premolars (P2, P3, P4) were bilaterally assigned to ARP in a total of n = 9 beagle dogs. Each P was decapitated and hemisected under preservation of the mesial (i.e., devitalization and filling with calcium hydroxide) and removal of the distal root. The resulting 6 extraction sockets were randomly allocated to a total of four injectable test materials (i.e., bovine bone particles + porcine collagen, lyophilized materials reconstituted with either blood or saline [T1, T2, T4]; or ready-to-use wet material [T3]) and one control material (collagenated bovine bone mineral) (C) as well as one negative control group (N). Primary wound closure was ensured in all test and C groups. At 12 weeks, dissected blocks were prepared for histomorphometrical analyses. Buccal bone height (BBH) was defined as a primary outcome. Lingual bone height (LBH), buccal and lingual bone wall width (BBW and LBW 1, 3 and 5 mm infracrestally), surface area of bone and particles, fibrous tissues, and bone marrows were defined as secondary outcomes. Between-group comparisons were assessed using ANOVA and Mann-Whitney tests.
RESULTS: After 12 weeks, all groups were associated with similar BBH values (BBH: 14.1, 14.0, 13.7, 13.8, 14.3 and 114.2 mm in the T1, T2, T3, T4, C and N groups, respectively; p > 0.05 for all between-group comparisons). The BBW and LBW measurements were comparable among the groups. ARP sites showed a trend towards higher area measurements of bone and particle surfaces compared with the N group (11.5, 11.6, 13.1, 12.5, 9.1 mm2 in T1, T2, T3, T4, C and N groups, respectively). C, T1, T2, T3 and T4 particles were associated with a similar marked grade of osteoconduction and osteointegration within the former extraction socket area.
CONCLUSIONS: Within its limitations, the present study has pointed to the similar efficacy of injectable bone fillers for ARP compared with the particulated bone substitute and negative control.