American journal of translational research · 2026
Rapid fire needling combined with Xiaoliu Jin Jianwei decoction improves gastrointestinal symptoms and gastric mucosal lesions in chronic atrophic gastritis.
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Li Tiejun, Wang Yali, Wang Zhenxing
Аннотация
OBJECTIVE: To investigate the efficacy of rapid-fire needling combined with Xiaoliu Jin Jianwei Decoction in chronic atrophic gastritis (CAG) and explore factors influencing the therapeutic effect.
METHODS: A total of 187 CAG patients admitted to our hsopital from April 2022 to April 2024 were divided into a control group (n=81, Xiaoliu Jin Jianwei Decoction alone) and an observation group (n=106, combined therapy), both receiving conventional drugs. After 4-weeks of treatment, GSRS score, total effective rate, gastric mucosal histopathology score and inflammatory factors were compared. Univariate and multivariate Logistic regression identified the influencing factors; a Nomogram model was constructed and verified by receiver operating characteristic (ROC) and calibration curves.
RESULTS: The observation group showed lower GSRS, histopathology scores, high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) levels, and higher total effective rate (93.40% vs 71.60%) than the control group (all P<0.05), with no difference in adverse reactions (P>0.05). GSRS score, histopathology score, hs-CRP, TNF-α and dietary habits were independent risk factors for poor efficacy. The Nomogram model had good predictive accuracy. Irregular diet was associated with higher GSRS, hs-CRP and TNF-α (P<0.05).
CONCLUSION: Combined therapy effectively improves gastrointestinal symptoms, reverses gastric mucosal lesions and enhances efficacy in CAG with good safety. The aforementioned indicators and dietary habits are key influencing factors.
METHODS: A total of 187 CAG patients admitted to our hsopital from April 2022 to April 2024 were divided into a control group (n=81, Xiaoliu Jin Jianwei Decoction alone) and an observation group (n=106, combined therapy), both receiving conventional drugs. After 4-weeks of treatment, GSRS score, total effective rate, gastric mucosal histopathology score and inflammatory factors were compared. Univariate and multivariate Logistic regression identified the influencing factors; a Nomogram model was constructed and verified by receiver operating characteristic (ROC) and calibration curves.
RESULTS: The observation group showed lower GSRS, histopathology scores, high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) levels, and higher total effective rate (93.40% vs 71.60%) than the control group (all P<0.05), with no difference in adverse reactions (P>0.05). GSRS score, histopathology score, hs-CRP, TNF-α and dietary habits were independent risk factors for poor efficacy. The Nomogram model had good predictive accuracy. Irregular diet was associated with higher GSRS, hs-CRP and TNF-α (P<0.05).
CONCLUSION: Combined therapy effectively improves gastrointestinal symptoms, reverses gastric mucosal lesions and enhances efficacy in CAG with good safety. The aforementioned indicators and dietary habits are key influencing factors.