Classification and recommendations of the Mexican Group for the study of Psoriasis and Other Immune-Mediated Diseases (PSOMEX) for the diagnosis and treatment of generalized pustular psoriasis.

Generalized pustular psoriasis is a rare, clinically heterogeneous autoinflammatory disease associated with significant morbidity and mortality. There are still many questions and unmet needs regarding basic concepts of the disease, although advances in the knowledge of its pathophysiological and genetic bases are leading to a change in it's concept, classification and treatment. Likewise, these advances have allowed the development of effective treatments with good therapeutic responses. After an exhaustive review of the literature, and based on the clinical experience of the authors, the Mexican Group for the Study of Psoriasis and Immune-Mediated Diseases (PSOMEX) provides in this article current information on the classification, diagnosis, clinical approach and treatment of generalized pustular psoriasis, as well as some recommendations for its management.