Clinical journal of the American Society of Nephrology : CJASN · 2017
Statistical Methods for Recurrent Event Analysis in Cohort Studies of CKD.
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Yang Wei, Jepson Christopher, Xie Dawei, Roy Jason A, Shou Haochang, Hsu Jesse Yenchih, Anderson Amanda Hyre, Landis J Richard, He Jiang, Feldman Harold I, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Аннотация
Cardiovascular events, such as hospitalizations because of congestive heart failure, often occur repeatedly in patients with CKD. Many studies focus on analyses of the first occurrence of these events, and discard subsequent information. In this article, we review a number of statistical methods for analyzing ordered recurrent events of the same type, including Poisson regression and three commonly used survival models that are extensions of Cox proportional hazards regression. We illustrate the models by analyzing data from the Chronic Renal Insufficiency Cohort Study to identify risk factors for congestive heart failure hospitalizations in patients with CKD. We show that recurrent event analyses provide additional insights about the data compared with a standard survival analysis of time to the first event.