The effect of myometrial invasion on prognostic factors and survival analysis in endometrial carcinoma.

BACKGROUND

We investigated the relationship between myometrial invasion and the prognostic factors on overall and progression free survival in endometrial carcinoma.

METHODS

122 cases operated with endometrial cancer were included into the study. Progression-free survival and overall survival were evaluated according to degree of myometrial invasion. We also investigated the relationship between myometrial invasion and prognostic factors.

RESULTS

The 5- year progression-free survival rate was 90 % in stage I, 66 % in stage II, 32 % in stage III and 60 % in stage IV. The 5- year overall survival rate was 95 % in stage I, 89 % in stage II, 49 % in stage III and 30 % in stage IV. The progression free survival and overall survival for patients with more than 50 % myometrial invasion were detected 67 % at 58 months and 66 % at 60 months, respectively. The clinicopathological variables that significantly correlated with myometrial invasion of more than 50 % were as follows: pelvic lymph node metastasis (p: 0,00029-OR: 11.2), cervical stromal invasion (p: 0008-OR:7.9), LVSI (p< 0.0001-OR: 16.5).

CONCLUSION

The depth of myometrial invasion is one of the most important prognostic indicators and determinants of therapy in endometrial cancer.