Head & neck · 2010
Expression of placenta growth factor: an independent factor for prediction of progression and prognosis of oral cancer.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cheng Shih-Jung, Lee Jang-Jaer, Kok Sang-Heng, Chou Chia-Hsuan, Chang Hao-Hueng, Chiang Meng Ling, Chen Hsin-Ming, Kuo Mark Yen-Ping, Chiang Chun-Pin
Аннотация
BACKGROUND: Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers.
METHODS: This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC).
RESULTS: We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p = .014) or with more advanced clinical stages (p = .016). Positive lymph node metastasis (p = .008) and PlGF labeling index >40% (p = .010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p = .003).
CONCLUSIONS: The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.
METHODS: This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC).
RESULTS: We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p = .014) or with more advanced clinical stages (p = .016). Positive lymph node metastasis (p = .008) and PlGF labeling index >40% (p = .010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p = .003).
CONCLUSIONS: The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.