Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026
Chronic erythema nodosum leprosum in Hansen's disease: a challenging clinical management.
СтатьяНазвание и аннотация: Перевод в очереди
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Spinicci Michele, Barbiero Anna, Manciulli Tommaso, Fiorelli Costanza, Fedi Roberto, Bussotti Alessandro, Silvestri Elena, Malandrino Danilo, Emmi Giacomo, Gazzoli Giovanni, Zammarchi Lorenzo, Bartoloni Alessandro
Аннотация
INTRODUCTION: Chronic erythema nodosum leprosum (ENL) is a challenging complication of Hansen's disease (HD), with limited treatment options and frequent steroid dependence. Anti-tumour necrosis factor (TNF)-α agents are promising alternatives, though evidence remains confined to a few reports.
CASE DESCRIPTION: We report the case of a 34-year-old Moroccan man with multibacillary Hansen's disease, who developed chronic ENL with recurrent systemic and cutaneous flares, requiring prolonged immunomodulatory therapy. Corticosteroids, thalidomide, azathioprine, methotrexate, and anti-TNF-α therapy only provided incomplete control. After six years of recurrences requiring several hospitalizations, treatment with methylprednisolone, high-dose thalidomide, and clofazimine achieved a sustained remission, allowing gradual treatment discontinuation.
CASE DESCRIPTION: We report the case of a 34-year-old Moroccan man with multibacillary Hansen's disease, who developed chronic ENL with recurrent systemic and cutaneous flares, requiring prolonged immunomodulatory therapy. Corticosteroids, thalidomide, azathioprine, methotrexate, and anti-TNF-α therapy only provided incomplete control. After six years of recurrences requiring several hospitalizations, treatment with methylprednisolone, high-dose thalidomide, and clofazimine achieved a sustained remission, allowing gradual treatment discontinuation.