[Effect of garlicin on unstable angina pectoris and its relationship with blood lipid and GMP-140].

OBJECTIVE

To observe the clinical effect of Garlicin on unstable angina pectoris (UAP) and to explore the relationship between Garlicin's effect and Syndrome Differentiation of TCM.

METHODS

Fifty-five patients of UAP were divided randomly into the Garllcin group (34 cases) and the control group (21 cases) and classified based on Syndrome Differentiation of TCM into Cold Syndrome type, Heat Syndrome type, severe blood stasis (SBS) type or mild blood stasis (MBS) type. Garlicin 60 mg or nitroglycerin 5 mg were given to the two groups respectively by intravenous drip for 10 days as one therapeutic course. The curatic effect was evaluated by changes of symptoms and electrocardiogram, and some indexes, such as blood lipid, lipoprotein, apolipoprotein and GMP-140 among different groups and types were compared.

RESULTS

The difference of effective rate between the Garlicin group and the control group was insignificant. In the Garlicin group, the effective rate of Cold Syndrome type was higher than that of Heat Syndrome type (P < 0.01), and HDL/LDL ratio and apoA1 level raised markedly in the former type (P < 0.05) while an oppositive trend revealed in the Heat Syndrome type. Garlicin showed a higher effect on SBS type than that on MBS type and cause GMP-140 of the MBS type decreased obviously.

CONCLUSION

Garlicin is effective on UAP patients and its effect was more evident on those with Cold Syndrome type or SBS type. Its mechanism may be related to its effect in improving blood lipid and enhancing activation of platelet.