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Войти в исследования World journal of clinical cases · 2025
Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma: Two case reports.
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Myrou Athena D, Spilioti Martha G, Tsolaki Anthoula C, Frontistis Antonis N, Savopoulos Christos G
Аннотация
BACKGROUND: Paraneoplastic limbic encephalitis (LE) is an inflammatory condition that affects the limbic system, cerebellum, and peripheral nervous system. It causes a range of symptoms including short-term memory loss, impaired cognitive function, behavioral and psychological disorders, and seizures. Paraneoplastic LE can occur when an immune response is activated due to antibodies targeting gamma-aminobutyric acid (GABA) B receptor (GABABR) interacting with antigens on tumor cells and the nervous system, resulting in tumors primarily as small cell lung carcinoma (SCLC).
CASE SUMMARY: We discuss two cases of GABABR antibody-related LE resulting from SCLC. The patients' symptoms were managed with immunotherapy but ended in premature death due to chemotherapy-related complications.
CONCLUSION: Paraneoplastic syndrome is a notable cause of LE. Early intravenous immunoglobulin therapy may lead to temporary remission.
CASE SUMMARY: We discuss two cases of GABABR antibody-related LE resulting from SCLC. The patients' symptoms were managed with immunotherapy but ended in premature death due to chemotherapy-related complications.
CONCLUSION: Paraneoplastic syndrome is a notable cause of LE. Early intravenous immunoglobulin therapy may lead to temporary remission.