BMC medical imaging · 2025
Preoperative pectoralis muscle index predicts distant metastasis-free survival in non-small cell lung cancer patients: a retrospective study.
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Shi Zhihui, Wu Lin, Jiang Dengke, Yang Ruiling, Liao Rui, Liu Lizhu, You Ruimin, Li Yanli, Dong Xingxiang, Zhang Dafu, Wang Jing, Zhang Xuewen, Chen Xiaobo, Li Zhenhui
Аннотация
BACKGROUND: Thoracic muscles contribute to respiration, is a crucial indicator for assessing functional recovery following lung resection. However, there is a lack of research on the long-term prognostic value of pectoralis muscle.
METHODS: Consecutive patients who underwent curative-intent resection for stage I to IIIA NSCLC between 2013 and 2018 at a cancer center were retrospectively identified. The Cox proportional hazard model was employed to analyze the correlation between pectoralis muscle index (PMI) and survival, with subgroup analyses conducted to explore potential heterogeneity among different subgroups. Finally, the relative influence of each parameter was compared using a gradient boosting model (GBM).
RESULTS: A total of 2110 patients (median (IQR) age 59 (52, 66) years) were evaluated. Kaplan-Meier survival analysis showed that the recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) rate of patients in the high PMI group were higher than those in the low PMI group, all with P < 0.001. In the multivariable analysis, low PMI is still associated with shorter RFS (HR = 1.34, 95% CI: (1.10, 1.62), P = 0.004), DMFS (HR = 1.35, 95% CI: (1.11, 1.65), P = 0.003), lung MFS (HR = 1.47, 95% CI: (1.19, 1.81), P < 0.001) and bone MFS (HR = 1.38, 95% CI: (1.11, 1.73), P = 0.004). These associations were consistent in subgroup analysis of different gender, age, tumor stage, histologic type, and surgical approach group.
CONCLUSIONS: Low PMI is significantly associated with worse distant metastasis-free survival (DMFS) and recurrence-free survival (RFS) in non-small cell lung cancer (NSCLC) patients, supporting its utility in refining preoperative risk stratification. When CT imaging lacks L3-level coverage, PMI offers a viable alternative for assessing muscle quality.
METHODS: Consecutive patients who underwent curative-intent resection for stage I to IIIA NSCLC between 2013 and 2018 at a cancer center were retrospectively identified. The Cox proportional hazard model was employed to analyze the correlation between pectoralis muscle index (PMI) and survival, with subgroup analyses conducted to explore potential heterogeneity among different subgroups. Finally, the relative influence of each parameter was compared using a gradient boosting model (GBM).
RESULTS: A total of 2110 patients (median (IQR) age 59 (52, 66) years) were evaluated. Kaplan-Meier survival analysis showed that the recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) rate of patients in the high PMI group were higher than those in the low PMI group, all with P < 0.001. In the multivariable analysis, low PMI is still associated with shorter RFS (HR = 1.34, 95% CI: (1.10, 1.62), P = 0.004), DMFS (HR = 1.35, 95% CI: (1.11, 1.65), P = 0.003), lung MFS (HR = 1.47, 95% CI: (1.19, 1.81), P < 0.001) and bone MFS (HR = 1.38, 95% CI: (1.11, 1.73), P = 0.004). These associations were consistent in subgroup analysis of different gender, age, tumor stage, histologic type, and surgical approach group.
CONCLUSIONS: Low PMI is significantly associated with worse distant metastasis-free survival (DMFS) and recurrence-free survival (RFS) in non-small cell lung cancer (NSCLC) patients, supporting its utility in refining preoperative risk stratification. When CT imaging lacks L3-level coverage, PMI offers a viable alternative for assessing muscle quality.