Locally administered antimicrobials for the management of periodontal infection.

Residual or persistent periodontal inflammation is associated with periodontal disease progression and tooth loss. Hence, resolving periodontal inflammation remains an important goal of periodontal treatment. Clinical trials consistently demonstrate that LAAs combined with SRP effectively reduce tissue inflammation in patients with chronic periodontitis. These changes are clinically relevant, and preliminary data suggest that this approach to periodontal treatment may be associated with improvements in systemic outcomes.