Zhonghua zhong liu za zhi [Chinese journal of oncology] · 1997
[Study of the relationship between the expression of Ki-67 antigen and the pathobiological behaviours of stomach cancer].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Xin Y, Wu D, Zhao F
Аннотация
OBJECTIVE: To evaluate the relationship between the expression of Ki-67 antigen and the pathobiological behaviours of stomach cancers especially their distant metastases.
METHODS: 56 stomach cancer specimens routinely fixed in formalin and embeded in paraffin (FFEP) were studied by immunohistochemical method.
RESULTS: Expression of Ki-67 antigen was significantly related to the distant metastases to liver, ovary and adrenal gland (P < 0.005); but not related to the histological type, growth pattern, depth of invasion, histological differentiation and the metastases to local lymph nodes (P > 0.05). Furthermore, the Ki-67 expression was significantly related to the DNA anueploid pattern and the expression of p53 protein, both of which are closely related to poor prognosis.
CONCLUSION: Overexpression of Ki-67 can be used as an objective marker of the proliferative activity for predicting prognosis of stomach cancer and to foretell the high-risk of metastasis of distant organs.
METHODS: 56 stomach cancer specimens routinely fixed in formalin and embeded in paraffin (FFEP) were studied by immunohistochemical method.
RESULTS: Expression of Ki-67 antigen was significantly related to the distant metastases to liver, ovary and adrenal gland (P < 0.005); but not related to the histological type, growth pattern, depth of invasion, histological differentiation and the metastases to local lymph nodes (P > 0.05). Furthermore, the Ki-67 expression was significantly related to the DNA anueploid pattern and the expression of p53 protein, both of which are closely related to poor prognosis.
CONCLUSION: Overexpression of Ki-67 can be used as an objective marker of the proliferative activity for predicting prognosis of stomach cancer and to foretell the high-risk of metastasis of distant organs.