Acta oto-laryngologica · 2026
Effects of metabolic tumor volume and total glycolytic activity on prognosis in oral cavity cancers.
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Büyük Bayram Barış, Kılıç Caner, Tunçcan Tuncay, Toprak Felat, Alkan Gökberk, Tosun Hüseyin Emre
Аннотация
BACKGROUND: Reliable prognostic imaging biomarkers are essential for improving risk stratification and treatment planning in patients with oral cavity cancer.
AIMS/OBJECTIVE: This study aimed to assess the prognostic significance of 18 F-FDG PET/CT-derived metabolic parameters, including SUVmax, metabolic tumor volume (MTV), and total glycolytic activity (TGA), in relation to disease-free survival (DFS) and overall survival (OS).
MATERIAL AND METHODS: This prospective study included 44 patients with newly diagnosed oral cavity cancer who underwent preoperative 18 F-FDG PET/CT imaging. SUVmax, MTV, and TGA values were recorded for the primary tumor. Survival analyses were performed using the Kaplan-Meier method with log-rank tests, and associations between PET-derived metabolic parameters and survival outcomes were evaluated using univariate Cox proportional hazards regression analysis.
RESULTS: During follow-up, disease recurrence occurred in 11 patients (25.0%) and 9 patients (20.5%) died. Kaplan-Meier analysis showed significantly shorter DFS in patients with higher TGA (≥16.65) and SUVmax (≥7.40), whereas MTV was not associated with DFS. No metabolic parameter showed a statistically significant association with OS, although higher TGA and SUVmax values demonstrated a trend toward poorer OS. In univariate Cox regression, TGA ≥16.65 was significantly associated with increased risk of recurrence or death (HR 6.31, 95% CI 1.34-29.64; p = 0.020).
CONCLUSION AND SIGNIFICANCE: TGA is a strong prognostic marker for DFS in oral cavity cancer and outperforms SUVmax and MTV in survival analysis.
AIMS/OBJECTIVE: This study aimed to assess the prognostic significance of 18 F-FDG PET/CT-derived metabolic parameters, including SUVmax, metabolic tumor volume (MTV), and total glycolytic activity (TGA), in relation to disease-free survival (DFS) and overall survival (OS).
MATERIAL AND METHODS: This prospective study included 44 patients with newly diagnosed oral cavity cancer who underwent preoperative 18 F-FDG PET/CT imaging. SUVmax, MTV, and TGA values were recorded for the primary tumor. Survival analyses were performed using the Kaplan-Meier method with log-rank tests, and associations between PET-derived metabolic parameters and survival outcomes were evaluated using univariate Cox proportional hazards regression analysis.
RESULTS: During follow-up, disease recurrence occurred in 11 patients (25.0%) and 9 patients (20.5%) died. Kaplan-Meier analysis showed significantly shorter DFS in patients with higher TGA (≥16.65) and SUVmax (≥7.40), whereas MTV was not associated with DFS. No metabolic parameter showed a statistically significant association with OS, although higher TGA and SUVmax values demonstrated a trend toward poorer OS. In univariate Cox regression, TGA ≥16.65 was significantly associated with increased risk of recurrence or death (HR 6.31, 95% CI 1.34-29.64; p = 0.020).
CONCLUSION AND SIGNIFICANCE: TGA is a strong prognostic marker for DFS in oral cavity cancer and outperforms SUVmax and MTV in survival analysis.