Leukemia & lymphoma · 2024
The impact of race and ethnicity on diffuse large B-cell lymphoma outcomes within the veterans health administration (VHA).
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Ta Andrew, Kaur Supreet, Mader Michael, Franklin Kathleen, Williams Madison, Williams Ryan, Blaize Jean-Pierre, Naqvi Amna, Ananth Snegha, Song Michael, Warnecke Brian Oliver, Pandya Abhishek, Djoumessi Lakene Raissa Djoufack, Nazarewicz Phillip, Espinoza-Gutarra Manuel, Lucero Kana Tai, Whitehead Jennifer, Al-Abayechi Alaq, Boyle Lauren, Lee Sophia, Roman Souza Gabriel, Toro Velez Esteban, Mines Ian, Nooruddin Zohra
Аннотация
We performed a retrospective chart review of 6266 randomly selected DLBCL patients treated in the VHA nationwide between 1/1/2011 and 12/31/2021. The 3178 patients who met inclusion criteria were predominantly male (97%) and white (75%). Median age of diagnosis for Black patients was 63 years vs 69 years for the entire cohort (p < 0.001). However, patients in each race/ethnicity subgroup presented with similar rates of stage I/II and III/IV disease, IPI score, cell of origin and HIT status. Outcomes analysis revealed similar treatment, response rates, median overall survival, and 1-, 3-, and 5-year survival across all subgroups. Hispanic patients had a 21% lower risk of death (HR = 0.79) than white patients, and Black patients had no significant difference in survival (HR = 0.98). This large retrospective study shows that when standard of care therapy is given within an equal access system, short-term treatment and survival outcomes are the same for all races.