European journal of anaesthesiology · 2025
Association between pre-operative borderline anaemia in women and outcome after coronary artery bypass grafting: data from the Netherlands Heart Registration.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hazen Yannick J J M, Noordzij Peter G, Van Der Maaten Joost M A A, Eberl Susanne, Ter Horst Maarten, Houterman Saskia, Berendsen Remco R, Bouwman R Arthur, Haenen Johannes S E, Hofland Jan, Kingma Marieke F, Van Klarenbosch Jan, Klok Toni, De Korte Marcel P J, Spanjersberg Alexander J, Wietsma Nicobert E, Gerritse Bastiaan M, Scohy Thierry V, van der Meer Nardo J M, Sarton Elise Y, Rettig Thijs C D, Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration
Аннотация
BACKGROUND: Haemoglobin concentration thresholds differ between men and women, with borderline anaemia (haemoglobin ≥ 12.1 and < 13.1 g dl -1 ) considered normal in women. However, this haemoglobin range may increase the risk of postoperative adverse outcomes after cardiac surgery.
OBJECTIVES: To determine if pre-operative borderline anaemia in women is associated with increased postoperative mortality and morbidity following coronary artery bypass grafting (CABG).
DESIGN: A retrospective observational cohort study.
SETTING: Data from The Netherlands Heart Registration, a national cardiac surgery registry, were used to analyse patients undergoing CABG from January 2013 to December 2020.
PATIENTS: A cohort of 7802 women undergoing CABG was analysed, of whom 25% ( n = 1963) had pre-operative borderline anaemia. Inclusion criteria were adult women undergoing isolated CABG; exclusion criteria included patients with severe anaemia or non-CABG procedures.
MAIN OUTCOME MEASURES: The primary outcome was 120-day mortality. Secondary outcomes included postoperative renal failure and need for packed red blood cell (PRBC) transfusion.
RESULTS: Borderline anaemia in women was not significantly associated with 120-day mortality (adjusted odds ratio [AOR] 1.2; 95% CI 0.8 to 1.9; P = 0.366). However, it was associated with an increased risk of renal failure (AOR 2.2; 95% CI 1.1 to 4.2; P = 0.031) and PRBC transfusion (AOR 2.1; 95% CI 1.8 to 2.3; P < 0.001).
CONCLUSIONS: Borderline anaemia, present in one-fourth of women undergoing CABG, does not increase mortality risk but is associated with higher postoperative morbidity, specifically renal failure and transfusion requirements.
OBJECTIVES: To determine if pre-operative borderline anaemia in women is associated with increased postoperative mortality and morbidity following coronary artery bypass grafting (CABG).
DESIGN: A retrospective observational cohort study.
SETTING: Data from The Netherlands Heart Registration, a national cardiac surgery registry, were used to analyse patients undergoing CABG from January 2013 to December 2020.
PATIENTS: A cohort of 7802 women undergoing CABG was analysed, of whom 25% ( n = 1963) had pre-operative borderline anaemia. Inclusion criteria were adult women undergoing isolated CABG; exclusion criteria included patients with severe anaemia or non-CABG procedures.
MAIN OUTCOME MEASURES: The primary outcome was 120-day mortality. Secondary outcomes included postoperative renal failure and need for packed red blood cell (PRBC) transfusion.
RESULTS: Borderline anaemia in women was not significantly associated with 120-day mortality (adjusted odds ratio [AOR] 1.2; 95% CI 0.8 to 1.9; P = 0.366). However, it was associated with an increased risk of renal failure (AOR 2.2; 95% CI 1.1 to 4.2; P = 0.031) and PRBC transfusion (AOR 2.1; 95% CI 1.8 to 2.3; P < 0.001).
CONCLUSIONS: Borderline anaemia, present in one-fourth of women undergoing CABG, does not increase mortality risk but is associated with higher postoperative morbidity, specifically renal failure and transfusion requirements.