[24-hour monitoring of gastric juice pH in assessment of anti-ulcer treatment].

AIM: Comparison of various schemes of three-component eradication of duodenal ulcer (DU) using 24-h monitoring of gastric juice pH.

MATERIALS AND

METHODS

62 DU patients in aggravation period have undergone 24-h monitoring of gastric juice pH and esophagogastroduodenoscopy with biopsy and H.pylori test of the treatment beginning and end. Patients of group 1 (n = 28) received ranitidin, metronidazole and amoxicillin while patients of group 2 (n = 34) took quamatel, metronidazole and amoxicillin.

RESULTS

24-h monitoring of pH of the gastric juice demonstrated that three-component therapy consisting of quamatel (20 mg/day, metronidazole (500 mg 4 times a day), amoxicillin (750 mg 3 times a day) maintains the level of intragastric acidity optimal for quick scarring of duodenal ulcer defect and led to eradication of H.pylori in 91.2% of cases.

CONCLUSION

24-h monitoring of gastric juice pH is a significant method of assessment of antiulcer treatment efficacy.