[Effect of prostaglandin F 2 alpha on the functional state of the tissue component of blood coagulation and fibrinolysis in albino rats with disorders of protein metabolism].

Experiments were made on 80 white rats to examine hemostatic and fibrinolytic properties of the liver, kidney, small intestine and skeletal muscle tissue and subcellular fractions (nuclei, mitochondria, nuclear supernatant liquid containing lysosomes, ribosomes, microsomes and with no mitochondria) during prostaglandin F2 alpha administration in the presence of upset protein metabolism induced by experimental toxic hepatitis and protein deficiency. It was shown that intravenous injection of prostaglandin F2 alpha leads to an increase in hemostatic properties and reduction of fibrinolytic activity of all the test tissues with the exception of gastric wall tissue which showed a different line of changes. Variation of hemostatic properties of whole tissues was followed by appropriate changes in hemocoagulation potential of subcellular fractions.