Medicine · 2020
Long-term remissions of young patients with high-risk follicular lymphoma after first-line autologous stem cell transplantation: Three case reports.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Lyu Rui, Wang Tingyu, Zou Dehui, Liu Wei, Yi Shuhua, Huang Wenyang, An Gang, Xu Yan, Li Zengjun, Qiu Lugui
Аннотация
RATIONALE: Autologous stem cell transplantation (ASCT) is not routinely recommended as first-line choice for follicular lymphoma (FL). However, we actually have observed that young patients with extremely high-risk factors benefit from ASCT. This study aims to speculate the rationality of ASCT as first-line treatment, through 3 cases and review of the literature.
PATIENT CONCERNS: 3 young-adult patients with FL received ASCT as first-line treatment.
DIAGNOSIS: All the 3 patients were no more than 30 years old and the diagnosis of FL was confirmed by histopathological and immunohistochemical evaluations. They all had multi-organ involvements, and two of them presented with a "leukemic-like" manifestation. Compared with those in the previous literatures, the 3 patients were relatively younger and had more invasive clinical features.
INTERVENTIONS: The 3 patients received combined chemotherapy plus rituximab, followed by first-line ASCT.
OUTCOMES: All the 3 patients got complete remission and minimal residual disease negativity after ASCT, The median follow-up time was 109 (97-117) months, and all of them were in remission more than 8 years after transplant.
LESSONS: Guidelines for FL are mainly based on elderly patients, but are not suitable enough for all, especially for the young FL patients. For young patients with certain high-risk FL, first-line ASCT does not go against the guidelines, and should be recommended individually.
PATIENT CONCERNS: 3 young-adult patients with FL received ASCT as first-line treatment.
DIAGNOSIS: All the 3 patients were no more than 30 years old and the diagnosis of FL was confirmed by histopathological and immunohistochemical evaluations. They all had multi-organ involvements, and two of them presented with a "leukemic-like" manifestation. Compared with those in the previous literatures, the 3 patients were relatively younger and had more invasive clinical features.
INTERVENTIONS: The 3 patients received combined chemotherapy plus rituximab, followed by first-line ASCT.
OUTCOMES: All the 3 patients got complete remission and minimal residual disease negativity after ASCT, The median follow-up time was 109 (97-117) months, and all of them were in remission more than 8 years after transplant.
LESSONS: Guidelines for FL are mainly based on elderly patients, but are not suitable enough for all, especially for the young FL patients. For young patients with certain high-risk FL, first-line ASCT does not go against the guidelines, and should be recommended individually.