Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025
In Vivo Volumetric Analysis of Endolymphatic Hydrops in Ménière Disease Using 7-Tesla MRI and Advanced Post-Processing.
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Ahmad Syed A, Kim Joon Soo, Jung Diane, Paez Adrian, Ding Andy S, Sun Yuanqi, Li Yinghao, Deng Francis, Carey John P, Hua Jun, Ward Bryan K
Аннотация
OBJECTIVE: To evaluate endolymphatic hydrops (EH) in patients with Meniere disease (MD) using high-resolution 7-tesla (7T) MRI volumetry with the goal of identifying anatomic differences that might clarify MD's etiology and inform therapeutic strategies.
STUDY DESIGN: Prospective cohort study.
SETTING: Tertiary referral center.
PATIENTS: Twelve adults with MD and 5 healthy controls met the inclusion criteria.
INTERVENTIONS: Participants underwent 7T MRI, including axial T2-weighted and 3D-FLAIR sequences, before and 4 hours after intravenous gadolinium-based contrast agent administration. Images were coregistered and subtracted to identify endolymph as a negative signal, followed by blinded manual segmentation.
MAIN OUTCOME MEASURES: Volumetric measurements of the membranous labyrinth [utricle+semicircular canals duct (SCC), saccule, cochlear duct, and total endolymph].
RESULTS: Fifteen MD-affected ears were compared with 10 healthy control ears. Median endolymph volumes were significantly larger in MD-affected ears in the utricle and SCC (99.53 vs. 55.29 mm 3 , P =0.033) but not in the saccule ( P =0.56) or cochlear duct ( P =0.21). The ratio of endolymph to total fluid inner ear fluid was also greater in MD-affected ears compared with controls (62.3% vs. 44.0%). Unaffected MD ears did not differ from their affected counterparts across compartments.
CONCLUSIONS: In vivo 7T MRI volumetry revealed significantly greater EH in the utricle and SCC of MD-affected ears versus controls, demonstrating its utility for characterizing EH and guiding more precise diagnostics and therapies. Future work must refine methods to reliably distinguish the utricle-saccule boundary-through improved imaging protocols or automated segmentation-to assess saccular hydrops in living patients.
STUDY DESIGN: Prospective cohort study.
SETTING: Tertiary referral center.
PATIENTS: Twelve adults with MD and 5 healthy controls met the inclusion criteria.
INTERVENTIONS: Participants underwent 7T MRI, including axial T2-weighted and 3D-FLAIR sequences, before and 4 hours after intravenous gadolinium-based contrast agent administration. Images were coregistered and subtracted to identify endolymph as a negative signal, followed by blinded manual segmentation.
MAIN OUTCOME MEASURES: Volumetric measurements of the membranous labyrinth [utricle+semicircular canals duct (SCC), saccule, cochlear duct, and total endolymph].
RESULTS: Fifteen MD-affected ears were compared with 10 healthy control ears. Median endolymph volumes were significantly larger in MD-affected ears in the utricle and SCC (99.53 vs. 55.29 mm 3 , P =0.033) but not in the saccule ( P =0.56) or cochlear duct ( P =0.21). The ratio of endolymph to total fluid inner ear fluid was also greater in MD-affected ears compared with controls (62.3% vs. 44.0%). Unaffected MD ears did not differ from their affected counterparts across compartments.
CONCLUSIONS: In vivo 7T MRI volumetry revealed significantly greater EH in the utricle and SCC of MD-affected ears versus controls, demonstrating its utility for characterizing EH and guiding more precise diagnostics and therapies. Future work must refine methods to reliably distinguish the utricle-saccule boundary-through improved imaging protocols or automated segmentation-to assess saccular hydrops in living patients.