Zhonghua bing li xue za zhi = Chinese journal of pathology · 2012
[Blastic plasmacytoid dendritic cell neoplasm: a clinicopathologic study].
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Sang Wei, Wang Chao-fu, Cheng Yu-fan, Liu Xia, Li Xin-xia, Gulinar Abulajiang, Li Jun-zhi, Zhang Wei
Аннотация
OBJECTIVE: To study the clinicopathologic features and differential diagnosis of blastic plasmacytoid dendritic cell neoplasm.
METHODS: The clinical, morphology and immunophenotypic features were analyzed in 3 cases of blastic plasmacytoid dendritic cell neoplasm, with review of literature.
RESULTS: The pathologic changes of these tumors accorded with that of blastic plasmacytoid dendritic cell neoplasm, and they also had new characteristics, including lineage other than T, B, myeloid and NK cells, and immunophenotypes of CD56(+) CD4(-) CD123(+) TdT(+) CD43(+) CD68(+) , CD56(+) CD4(+) CD123(-) TdT(+) CD43(+) CD68(-) and CD56(+) CD4(+) CD123(-/+) TdT(-) CD43(+) CD68(+) in the 3 cases, respectively. Bone marrow involvement was found 5 years later in case 1, and was then stable after chemotherapy; case 2 and case 3 were died 5 and 2 months after diagnosis, respectively.
CONCLUSION: Blastic plasmacytoid dendritic cell neoplasm is a heterogeneous group of lymphoproliferative disorders, with different clinical, morphologic and immunophenotypic features.
METHODS: The clinical, morphology and immunophenotypic features were analyzed in 3 cases of blastic plasmacytoid dendritic cell neoplasm, with review of literature.
RESULTS: The pathologic changes of these tumors accorded with that of blastic plasmacytoid dendritic cell neoplasm, and they also had new characteristics, including lineage other than T, B, myeloid and NK cells, and immunophenotypes of CD56(+) CD4(-) CD123(+) TdT(+) CD43(+) CD68(+) , CD56(+) CD4(+) CD123(-) TdT(+) CD43(+) CD68(-) and CD56(+) CD4(+) CD123(-/+) TdT(-) CD43(+) CD68(+) in the 3 cases, respectively. Bone marrow involvement was found 5 years later in case 1, and was then stable after chemotherapy; case 2 and case 3 were died 5 and 2 months after diagnosis, respectively.
CONCLUSION: Blastic plasmacytoid dendritic cell neoplasm is a heterogeneous group of lymphoproliferative disorders, with different clinical, morphologic and immunophenotypic features.
Предметные рубрики MeSH
AdolescentAntineoplastic Combined Chemotherapy ProtocolsBleomycinCD56 AntigenCyclophosphamideDendritic CellsDiagnosis, DifferentialDoxorubicinFemaleFollow-Up StudiesHematologic NeoplasmsHumansInterleukin-3 Receptor alpha SubunitLeukemia, MyeloidLymphoma, Extranodal NK-T-CellLymphoma, T-Cell, PeripheralMaleMiddle AgedPrecursor Cell Lymphoblastic Leukemia-LymphomaPrednisoneSkin NeoplasmsTreatment OutcomeVincristine