Blood · 2014
Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Muñiz Carmen, Martín-Martín Lourdes, López Antonio, Sánchez-González Blanca, Salar Antonio, Almeida Julia, Sancho Juan-Manuel, Ribera José María, Heras Cecilia, Peñalver Francisco Javier, Gómez Marta, González-Barca Eva, Alonso Natalia, Navarro Belén, Olave Teresa, Sala Francisco, Conde Eulogio, Márquez José Antonio, Cabezudo Elena, Cladera Antonia, García-Malo María, Caballero María Dolores, Orfao Alberto, Spanish Group for the Study of Central Nervous System Disease in Non-Hodgkin Lymphoma
Аннотация
Flow cytometry (FCM) is more sensitive than conventional cytology for detection of occult leptomeningeal lymphoma; however, some FCM-negative patients show central nervous system (CNS) recurrence. Here, we evaluated the cerebrospinal fluid (CSF) levels of 13 B-cell-associated markers and their contribution to the diagnosis of CNS lymphoma in 91 diffuse large B-cell lymphomas (DLBCL) and 22 Burkitt lymphomas (BLs). From all markers tested, CD19 was the most informative. Thus, higher soluble CD19 (sCD19) levels were associated with a greater frequency of neurological symptoms in DLBCL and BL and with parenchymal CNS lymphoma in DLBCL; sCD19 emerged as a powerful predictor of event-free and overall survival in DLBCL and BL, particularly when combined with FCM detection of CNS disease. These results support the utility of combined FCM detection of lymphoma cells and assessment of sCD19 levels in CSF, for more accurate identification of CNS disease in DLBCL and BL patients.