Internal medicine (Tokyo, Japan) · 2012
Immune reconstitution inflammatory syndrome mimics a relapse of AIDS-related Burkitt lymphoma.
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Fukunaga Akiko, Iwamoto Yoshihiro, Inano Shojiro, Sueki Yuki, Yoshinaga Noriyoshi, Yanagida Soshi, Arima Nobuyoshi
Аннотация
Immune reconstitution inflammatory syndrome (IRIS) is associated with clinical manifestations that can overlap with the patients with acquired immunodeficiency disease (AIDS)-related non-Hodgkin's lymphoma. We herein report a case of AIDS-related Burkitt lymphoma which was successfully treated with dose-adjusted etoposide, doxorubicin, cyclophosphamide, vincristine, and prednisone (EPOCH). However, the patient developed a lymphoma-like clinical presentation shortly after the conclusion of chemotherapy. The patient's symptoms were identical to the initial symptoms characteristic of lymphoma; however, the laboratory data revealed no evidence of a relapse of Burkitt lymphoma. A bone marrow examination showed T-cell clonality, even though there were no signs of any progression of the lymphoma. The patient was diagnosed with IRIS, and the clinical manifestations rapidly improved following treatment.