Nature genetics · 2012
The genetic landscape of mutations in Burkitt lymphoma.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Love Cassandra, Sun Zhen, Jima Dereje, Li Guojie, Zhang Jenny, Miles Rodney, Richards Kristy L, Dunphy Cherie H, Choi William W L, Srivastava Gopesh, Lugar Patricia L, Rizzieri David A, Lagoo Anand S, Bernal-Mizrachi Leon, Mann Karen P, Flowers Christopher R, Naresh Kikkeri N, Evens Andrew M, Chadburn Amy, Gordon Leo I, Czader Magdalena B, Gill Javed I, Hsi Eric D, Greenough Adrienne, Moffitt Andrea B, McKinney Matthew, Banerjee Anjishnu, Grubor Vladimir, Levy Shawn, Dunson David B, Dave Sandeep S
Аннотация
Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual. We further sequenced the exomes of 59 Burkitt lymphoma tumors and compared them to sequenced exomes from 94 diffuse large B-cell lymphoma (DLBCL) tumors. We identified 70 genes that were recurrently mutated in Burkitt lymphomas, including ID3, GNA13, RET, PIK3R1 and the SWI/SNF genes ARID1A and SMARCA4. Our data implicate a number of genes in cancer for the first time, including CCT6B, SALL3, FTCD and PC. ID3 mutations occurred in 34% of Burkitt lymphomas and not in DLBCLs. We show experimentally that ID3 mutations promote cell cycle progression and proliferation. Our work thus elucidates commonly occurring gene-coding mutations in Burkitt lymphoma and implicates ID3 as a new tumor suppressor gene.
Предметные рубрики MeSH
Ammonia-LyasesBase SequenceBurkitt LymphomaCell Line, TumorChaperonin Containing TCP-1DNA HelicasesDNA-Binding ProteinsGTP-Binding Protein alpha Subunits, G12-G13Genes, mycGenome, HumanGlutamate FormimidoyltransferaseHomeodomain ProteinsHumansInhibitor of Differentiation ProteinsIntracellular Signaling Peptides and ProteinsLymphoma, Large B-Cell, DiffuseMembrane ProteinsMolecular Sequence DataMultifunctional EnzymesMutationNeoplasm ProteinsNuclear ProteinsProto-Oncogene Proteins c-retSequence Analysis, DNATranscription FactorsTranslocation, Genetic