Clinical significance in combined detection of serum pepsinogen I, pepsinogen II and carbohydrate antigen 242 in gastric cancer.

BACKGROUND/AIMS: To explore the diagnosis value and clinical significance of combined detection of serum pepsinogen I (PG I), pepsinogen II (PG II), PG I/II and CA242 in patients with stomach diseases.

METHODOLOGY: Serum PG I, PG II and CA242 were detected with time-resolved fluoroimmunoassay (TRFIA) method. Serum levers of the four markers in gastric carcinoma were compared with that in chronic superficial gastritis, chronic atrophic gastritis, gastric ulcer and normal controls. The four indices were analyzed to judge their diagnosis value and the relationship with the biology behavior of gastric carcinoma.

RESULTS

The serum concentration of PG I in gastric carcinoma and in chronic atrophic gastritis were remarkably lower than that in controls (P < 0.05). The serum concentration of CA242 in gastric carcinoma was significantly higher than that in controls (P < 0.05).

CONCLUSIONS

To detect the levers of serum PG I, PG II, PG I/II would help to judge the metastasis and prognosis of gastric carcinoma. Combined detection of the four indices could increase the positive rate of diagnosis in gastric carcinoma.