Clinical and experimental dermatology · 2014
Transforming growth factor-β1 gene polymorphism in mycosis fungoides.
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Zayed A A, Abdel-Halim M R E, Sayed K S, Mohammed F N, Hany D M, Amr K S
Аннотация
BACKGROUND: Dysregulation in transforming growth factor (TGF)-β1 signalling pathways has been linked to cancer.
AIM: To study the association between single nucleotide polymorphisms (SNPs) of the TGF-β1 gene and mycosis fungoides (MF).
METHODS: Using restriction fragment length polymorphism analysis, SNPs in the TGF-β1 gene were studied in 55 patients with MF of different stages and in 100 apparently healthy controls.
RESULTS: A significant difference was found between patients and controls in distribution of the different TGF-β1 genotypes, with mutant forms (T/C, T/T) encountered significantly more often in patients with MF (P < 0.001). The heterozygous genotype (T/C) was significantly associated with patch stage MF, whereas the homozygous genotype (T/T) was significantly associated with tumour stage (stage IIb) MF (P = 0.001), although this study included only a small number of these patients.
CONCLUSIONS: Mutant TGF-β1 genotypes are significantly associated with MF in Egyptian patients, with the homozygous genotype (T/T) having a stronger association with tumour stage (stage IIb).
AIM: To study the association between single nucleotide polymorphisms (SNPs) of the TGF-β1 gene and mycosis fungoides (MF).
METHODS: Using restriction fragment length polymorphism analysis, SNPs in the TGF-β1 gene were studied in 55 patients with MF of different stages and in 100 apparently healthy controls.
RESULTS: A significant difference was found between patients and controls in distribution of the different TGF-β1 genotypes, with mutant forms (T/C, T/T) encountered significantly more often in patients with MF (P < 0.001). The heterozygous genotype (T/C) was significantly associated with patch stage MF, whereas the homozygous genotype (T/T) was significantly associated with tumour stage (stage IIb) MF (P = 0.001), although this study included only a small number of these patients.
CONCLUSIONS: Mutant TGF-β1 genotypes are significantly associated with MF in Egyptian patients, with the homozygous genotype (T/T) having a stronger association with tumour stage (stage IIb).