Zhongguo shi yan xue ye xue za zhi · 2017
[Clinical Significance of Peripheral blood EB Virus Detection in NK/T Cell Lymphoma Patients].
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Zhang Jing, Yue Lei, Li Ying-Lu
Аннотация
OBJECTIVE: To explore the clinical significance of peripheral blood EB virus detection in NK/T cell lymphoma patients.
METHODS: The positive rate of EB virus and EBV-DNA in 85 cases of NK/T cell lymphoma was assayed; the correlation of positive rate of EB virus with clinical staging, short-term and long-term prognosis was analyzed.
RESULTS: The positive rate of EB virus in NK/T cell lymphoma was high (80.00%). The EBV-DNA copy number in peripheral blood leukocytes was higher than that in peripheral plasma (P<0.05), but there was no significant difference in EBV-DNA level between peripheral leukocytes and serum (P>0.05). The I-II stages ratio of patients in EBV+ group was significantly lower than that in EBV- group. The CR rate and ORR in EBV+ group was significantly lower than those in EBV- group, the 3 year OS rate and 3 year DFR in EBV+ group also was significantly lower than those in EBV- group.
CONCLUSION: The detection of periphera blood EBV may be used as an reference indicator for anxiliary diagnosis of NK/T cell lymphoma and evaluation of prognosis for patients, thus possessing a certain value for clinical application.
METHODS: The positive rate of EB virus and EBV-DNA in 85 cases of NK/T cell lymphoma was assayed; the correlation of positive rate of EB virus with clinical staging, short-term and long-term prognosis was analyzed.
RESULTS: The positive rate of EB virus in NK/T cell lymphoma was high (80.00%). The EBV-DNA copy number in peripheral blood leukocytes was higher than that in peripheral plasma (P<0.05), but there was no significant difference in EBV-DNA level between peripheral leukocytes and serum (P>0.05). The I-II stages ratio of patients in EBV+ group was significantly lower than that in EBV- group. The CR rate and ORR in EBV+ group was significantly lower than those in EBV- group, the 3 year OS rate and 3 year DFR in EBV+ group also was significantly lower than those in EBV- group.
CONCLUSION: The detection of periphera blood EBV may be used as an reference indicator for anxiliary diagnosis of NK/T cell lymphoma and evaluation of prognosis for patients, thus possessing a certain value for clinical application.