Reviews on recent clinical trials · 2023
Cladribine Efficacy in a Patient with Hairy Cell Leukemia and Severe Renal Insufficiency.
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Gozzetti Alessandro, Bacchiarri Francesca, Raspadori Donatella, Sicuranza Anna, Sammartano Vincenzo, Bocchia Monica
Аннотация
BACKGROUND: Hairy cell leukemia commonly presents with pancytopenia, indolent course, and predisposition as infectious complications. Current first-line therapeutic options are purine analogues, particularly cladribine, with a high percentage of complete responses and durable remissions. However, their use is poorly investigated in patients affected by severe chronic renal insufficiency.
CASE PRESENTATION: Here, we describe a case of HCL in a 68-year-old man affected by multiple comorbidities, including severe chronic renal failure. After a course of interferon-α, the patient received therapy with Cladribine every other week, obtaining a complete hematological remission and improvement of renal function.
DISCUSSION: With a different soft schedule of cladribine, the patient was treated adequately, obtaining a complete remission.
CONCLUSION: Cladribine can be administered with caution, even in patients with renal failure, with good results.
CASE PRESENTATION: Here, we describe a case of HCL in a 68-year-old man affected by multiple comorbidities, including severe chronic renal failure. After a course of interferon-α, the patient received therapy with Cladribine every other week, obtaining a complete hematological remission and improvement of renal function.
DISCUSSION: With a different soft schedule of cladribine, the patient was treated adequately, obtaining a complete remission.
CONCLUSION: Cladribine can be administered with caution, even in patients with renal failure, with good results.