New microbes and new infections · 2026
Neutrophil-to-lymphocyte ratio as a biomarker in erythema nodosum leprosum: A systematic review and meta-analysis.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shadrina Siti Azyyati Nur, Karlina Starla Gracelie, Subhan Syalikha Arviandra, Kirana Arzetha, Putra Sit Ari Dwi, Najmamahanany Jihan Aliya, Putri Naila Qanita, Panggabean Adinda Cleo Putri, Ufaira Aulia Indra, Dahlianingsih Valentina Febri, Abdillah Muhammad Azi, Tear Alveron Andreas, Nugraha Naufal Fakhri
Аннотация
OBJECTIVES: Erythema nodosum leprosum (ENL) is a severe type 2 leprosy reaction causing recurrent episodes, nerve damage, and disability. Diagnosis still relies on clinical assessment and tests often unavailable in resource-limited settings. The neutrophil-to-lymphocyte ratio (NLR), derived from routine complete blood counts, has been proposed as a low-cost inflammatory biomarker. This systematic review and meta-analysis aimed to assess differences in NLR between ENL and non-reactional leprosy.
METHODS: Following PRISMA 2020 and a PECO framework, we searched PubMed, ScienceDirect, Scopus, and Google Scholar up to 20 November 2025 for observational studies reporting NLR in ENL versus non-reactional leprosy. Quality was assessed using the Newcastle-Ottawa Scale. Pooled mean differences were estimated using a fixed-effect model in RevMan 5.4.1, with heterogeneity evaluated by Cochran's Q and the I2 statistic.
RESULTS: Of 677 records, five observational studies (162 ENL and 423 non-reactional leprosy patients) met the inclusion criteria. NLR was higher in ENL, with a pooled mean difference of 5.79 (95% CI 4.58-6.99; I2 = 56%; P < 0.00001).
CONCLUSIONS: NLR is markedly elevated in ENL compared with non-reactional leprosy, supporting its potential as a simple, low-cost biomarker. Prospective studies are needed to define optimal cut-off values for routine use.
METHODS: Following PRISMA 2020 and a PECO framework, we searched PubMed, ScienceDirect, Scopus, and Google Scholar up to 20 November 2025 for observational studies reporting NLR in ENL versus non-reactional leprosy. Quality was assessed using the Newcastle-Ottawa Scale. Pooled mean differences were estimated using a fixed-effect model in RevMan 5.4.1, with heterogeneity evaluated by Cochran's Q and the I2 statistic.
RESULTS: Of 677 records, five observational studies (162 ENL and 423 non-reactional leprosy patients) met the inclusion criteria. NLR was higher in ENL, with a pooled mean difference of 5.79 (95% CI 4.58-6.99; I2 = 56%; P < 0.00001).
CONCLUSIONS: NLR is markedly elevated in ENL compared with non-reactional leprosy, supporting its potential as a simple, low-cost biomarker. Prospective studies are needed to define optimal cut-off values for routine use.