The American journal of gastroenterology · 2016
Predictive Factors for Differentiating Between Crohn's Disease and Intestinal Tuberculosis in Koreans.
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Jung Yunho, Hwangbo Young, Yoon Soon Man, Koo Hoon Sup, Shin Hyun Deok, Shin Jeong Eun, Moon Hee Seok, Kang Sang Bum, Lee Jeong Rok, Huh Kyu Chan
Аннотация
OBJECTIVES: A differential diagnosis between intestinal tuberculosis (ITB) and Crohn's disease (CD) is challenging. The aim of this study was to investigate the clinical, endoscopic, and histological features and to create a predictive score model for differentiating CD and ITB.
METHODS: In total, 261 patients, 99 with ITB and 162 with CD, were recruited from seven tertiary centers from 2005 to 2013 and reviewed retrospectively. For the creation of a validated model, parameters were selected by univariate logistic regression and receiver operating characteristic curve analyses. Then, the prediction model was established on the basis of β-coefficients of the multivariate logistic regression. For the validation of the model, the same regression equation was tested on the other group.
RESULTS: Age, diarrhea, ring-shaped ulcer, longitudinal ulcer, sigmoid involvement, suspicious radiological pulmonary tuberculosis, and gender were selected as the factors for a seven-marker model. In the seven-marker model of the validation data set, the sensitivity, specificity, positive predictive value, and negative predictive value with a cutoff level of 0.35 were 98.0, 92.4, 88.9, and 98.6, respectively.
CONCLUSIONS: The seven-marker model seems to be highly reliable for differentiating between ITB and CD and could be conveniently used by clinicians to obtain results.
METHODS: In total, 261 patients, 99 with ITB and 162 with CD, were recruited from seven tertiary centers from 2005 to 2013 and reviewed retrospectively. For the creation of a validated model, parameters were selected by univariate logistic regression and receiver operating characteristic curve analyses. Then, the prediction model was established on the basis of β-coefficients of the multivariate logistic regression. For the validation of the model, the same regression equation was tested on the other group.
RESULTS: Age, diarrhea, ring-shaped ulcer, longitudinal ulcer, sigmoid involvement, suspicious radiological pulmonary tuberculosis, and gender were selected as the factors for a seven-marker model. In the seven-marker model of the validation data set, the sensitivity, specificity, positive predictive value, and negative predictive value with a cutoff level of 0.35 were 98.0, 92.4, 88.9, and 98.6, respectively.
CONCLUSIONS: The seven-marker model seems to be highly reliable for differentiating between ITB and CD and could be conveniently used by clinicians to obtain results.
Предметные рубрики MeSH
Abdominal PainAdolescentAdultAge FactorsAgedAnus DiseasesColonoscopyCrohn DiseaseDiagnosis, DifferentialDiarrheaFemaleHumansLogistic ModelsMaleMiddle AgedROC CurveRadiography, ThoracicRepublic of KoreaRetrospective StudiesSensitivity and SpecificitySex FactorsSigmoid DiseasesTuberculosis, GastrointestinalTuberculosis, PulmonaryUlcerYoung Adult