Circulation journal : official journal of the Japanese Circulation Society · 2010
Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment.
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Teramoto Tomohiko, Ikeno Fumiaki, Otake Hiromasa, Lyons Jennifer K, van Beusekom Heleen M M, Fearon William F, Yeung Alan C
Аннотация
BACKGROUND: Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented.
METHODS AND RESULTS: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA.
CONCLUSIONS: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.
METHODS AND RESULTS: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA.
CONCLUSIONS: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.