Медицинская библиотека · European journal of gastroenterology & hepatology · 2018

Short article: Hepatitis delta in patients with resolved hepatitis B virus infection.

Aguilera Antonio, Rodríguez-Calviño Javier, de Mendoza Carmen, Soriano Vincent

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Аннотация

BACKGROUND

The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset shows elevated liver enzymes and hepatic fibrosis. Could they represent HBsAg-seronegative occult HDV infections?

METHODS

We tested for HDV-antibodies 406 individuals with markers of past HBV exposure.

RESULTS

Overall, 20 (4.9%) were reactive for HDV-antibodies. All were negative for serum HDV-RNA, including four with elevated liver enzymes.

CONCLUSION

These results support the current policy of screening for hepatitis delta only in HBsAg+ individuals.

Для цитирования: Aguilera Antonio, Rodríguez-Calviño Javier, de Mendoza Carmen, Soriano Vincent. Short article: Hepatitis delta in patients with resolved hepatitis B virus infection.. European journal of gastroenterology & hepatology. 2018. DOI: 10.1097/meg.0000000000001187.

Предметные рубрики MeSH

Adult Aged Alanine Transaminase Antiviral Agents Aspartate Aminotransferases Clinical Decision-Making Coinfection Female Hepatitis Antibodies Hepatitis B Hepatitis B Surface Antigens Hepatitis D Hepatitis Delta Virus Humans Male Middle Aged Predictive Value of Tests RNA, Viral

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