Ursodeoxycholate in primary biliary cirrhosis any--different from the rest?

Effective therapy for primary biliary cirrhosis is lacking but not for want of appropriate immunosuppressive, antifibrotic, and cupruretic agents. A consensus as to which agent, if any, to use has not been reached. Recent studies suggest that ursodeoxycholate may be both safe and effective. However, the long-term response to this hydrophilic bile acid is still unknown.