Zhongguo shi yan xue ye xue za zhi · 2026
[The Prevalence and Epidemiological Characteristics of Monoclonal Gammopathy of Undetermined Significance in the Healthy Individuals of Daqing Region].
СтатьяАннотация на английскомНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhou Xiao-Na, Hu Chun-Ling, Li Jia-Jia, Zhang Wei-Wei, Zhang Li-Na
Аннотация
OBJECTIVE: Through the screening of serum and urine M protein in the health examination population in Daqing area, the prevalence rate, age/gender distribution characteristics and subtype composition of monoclonal gammopathy of undetermined significance (MGUS) were clarified, providing baseline data for the early screening of plasma cell diseases in Northeast China.
METHODS: A prospective observational study design was adopted, 1137 healthy individuals aged 30 and above (715 males and 422 females) in Daqing City Examination Center between July and September 2023 were included in this study. Screening for M protein was initially conducted through serum protein electrophoresis (SPE) and urine protein electrophoresis, and positive samples were confirmed by serum or urine immunofixation electrophoresis (IFE) for MGUS. Statistical analysis was performed using the Cochran-Armitage trend test, Fisher's exact test, and multivariate logistic regression analysis.
RESULTS: Among 1137 healthy individuals aged 30 and above, 18 cases of MGUS were diagnosed, with a total prevalence of 1.58% (18/1137). The prevalence of MGUS in those over 40 years old was 1.66% (15/903). The prevalence of MGUS significantly increased with age (P=0.003). There was no significant difference in prevalence between males and females (1.68%vs. 1.42%, P=0.811). The subtype distribution of MGUS was dominated by IgG type, accounting for 77.78% (14/18), followed by IgA type at 16.67% (3/18), and light chain type at 5.56% (1/18). No IgM type or biclonal type was detected. Age ≥60 years was an independent risk factor for MGUS (adjusted or=4.37, 95%CI: 1.42-13.45, P=0.010).
CONCLUSION: The prevalence of MGUS in Daqing area is approximately 1.58%, with no gender difference and a positive correlation with age. The predominant subtype is IgG type.
METHODS: A prospective observational study design was adopted, 1137 healthy individuals aged 30 and above (715 males and 422 females) in Daqing City Examination Center between July and September 2023 were included in this study. Screening for M protein was initially conducted through serum protein electrophoresis (SPE) and urine protein electrophoresis, and positive samples were confirmed by serum or urine immunofixation electrophoresis (IFE) for MGUS. Statistical analysis was performed using the Cochran-Armitage trend test, Fisher's exact test, and multivariate logistic regression analysis.
RESULTS: Among 1137 healthy individuals aged 30 and above, 18 cases of MGUS were diagnosed, with a total prevalence of 1.58% (18/1137). The prevalence of MGUS in those over 40 years old was 1.66% (15/903). The prevalence of MGUS significantly increased with age (P=0.003). There was no significant difference in prevalence between males and females (1.68%vs. 1.42%, P=0.811). The subtype distribution of MGUS was dominated by IgG type, accounting for 77.78% (14/18), followed by IgA type at 16.67% (3/18), and light chain type at 5.56% (1/18). No IgM type or biclonal type was detected. Age ≥60 years was an independent risk factor for MGUS (adjusted or=4.37, 95%CI: 1.42-13.45, P=0.010).
CONCLUSION: The prevalence of MGUS in Daqing area is approximately 1.58%, with no gender difference and a positive correlation with age. The predominant subtype is IgG type.