Reference intervals for coagulation times using two point-of-care analysers in healthy pet rabbits (Oryctolagus cuniculus).

The purpose of this study was to establish reference intervals for prothrombin time (PT) and activated partial prothrombin time (aPTT) in healthy rabbits using two different point-of-care analysers (Idexx Coag DX and MS Quick Vet Coag Combo). These intervals would be useful in the diagnosis of coagulopathies and in the determination of coagulation status in critical patients. We are unaware of reports of coagulation values in pet rabbits. Blood samples were analysed from 81 clinically healthy pet rabbits under three years of age (49 females and 32 males). The reference intervals were as follows (non-parametric method for the MS Quick Vet Coag Combo and Box-Cox Robust method for the Idexx Coag DX, p<0.05 limit for statistical significance): PT (MS Quick Vet Coag Combo)=N=33, 17.2-28.5; PT (Idexx Coag DX)=N=48, 10.0-14.8, aPTT (MS Quick Vet Coag Combo)=N=33, 103.2-159.2 and aPTT (Idexx Coag DX)=N=48, 104.2-159.1. PT was significantly longer using the MS Quick Vet Coag Combo. aPTT was significantly shorter with the MS Quick Vet Coag Combo. On each type of analyser, there was no significant difference between sexes and blood sampling sites. A significant difference was present for the use or not of anaesthesia with the MS Quick Vet Coag Combo analyser. This study on healthy pet rabbits will be useful in point-of-care diagnosis of coagulopathies.