Case reports in neurology · 2025
Stiff-Person Syndrome with Anti-Amphiphysin Antibodies: A Paraneoplastic Phenomenon Revealing Breast Cancer in a 77-Year-Old Male.
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Geyskens Michael, Roos Dareia S, Konings Inge R, Gorter de Vries Cathelijne, Raijmakers Pieter, Schutte Tim
Аннотация
INTRODUCTION: Stiff-person syndrome is a neurological disorder characterized by painful muscle cramps and progressive muscle spasticity. In patients with positive anti-amphiphysin antibodies, there is an association with malignancies such as breast carcinomas and small cell lung cancers.
CASE PRESENTATION: We report the case of a 77-year-old male patient who developed symptoms of anti-amphiphysin positive stiff-person syndrome and was diagnosed with breast cancer. After immunomodulatory and curative-intent oncological treatment, the patient experienced marked improvement in his neurological symptoms.
CONCLUSION: This case is an example of the importance of multidisciplinary care and thorough oncological workup in a case of stiff-person syndrome with positive anti-amphiphysin antibodies.
CASE PRESENTATION: We report the case of a 77-year-old male patient who developed symptoms of anti-amphiphysin positive stiff-person syndrome and was diagnosed with breast cancer. After immunomodulatory and curative-intent oncological treatment, the patient experienced marked improvement in his neurological symptoms.
CONCLUSION: This case is an example of the importance of multidisciplinary care and thorough oncological workup in a case of stiff-person syndrome with positive anti-amphiphysin antibodies.