Professor Alan H.B. Wu: Contributions that will stand the test of time.

This article honors Dr. Alan H.B. Wu's 25-year leadership as Editor-in-Chief of Clinica Chimica Acta and his transformative contributions to clinical chemistry and laboratory medicine. A central focus of his career has been advancing the use of cardiac biomarkers, particularly cardiac troponin (cTn) and natriuretic peptides, for the diagnosis and management of myocardial infarction and heart failure. Dr. Wu's studies helped establish the diagnostic and prognostic value of cTn, contributed to standardization and high-sensitivity assay development, and explored novel technologies. His work on biological variability emphasized the limitations of population-based reference intervals and promoted individualized interpretation of test results. Through guidelines and collaborations, Dr. Wu has shaped biomarker adoption, clinical practice, and laboratory quality standards. His vision of personalized laboratory medicine continues to advance diagnostics and improve patient care.