The Gulf journal of oncology · 2025
Comparative Evaluation of Dosimetric Parameters in Carcinoma Cervix Patients Undergoing Intensity-Modulated Radiotherapy versus Three-Dimensional Radiotherapy: A Retrospective Analysis.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Mishra Vishwadeep, Bisht Sudeep, Chaudhary Shwetima, Pandey Laxman, Pandey Archana, Chatterjee Rachita
Аннотация
OBJECTIVE: Cervical cancer affects many women across the globe and often requires radiation for treatment. This study aimed to compare the dosimetric outcomes of Intensity-Modulated Radiation Therapy (IMRT) and Three- Dimensional Conformal Radiation Therapy (3D-CRT) in managing locally advanced cervical carcinoma.
METHODS: We performed a retrospective analysis of 30 patients who received IMRT with weekly cisplatin-based medication. Corresponding 3DCRT plans were generated for comparison. Dosimetric parameters for Planning Target Volume (PTV) and Organs at Risk (OARs) were evaluated. Patients were immobilized in a supine position for simulation, according to conventional protocols.
RESULTS: PTV coverage was similar between IMRT and 3D-CRT groups. However, IMRT showed significantly improved dosimetric outcomes for OARs, including the bladder, rectum, bowel, and bone marrow. IMRT reduced doses to critical organs while maintaining comparable PTV coverage.
CONCLUSION: Patients undergoing IMRT experienced reduced doses to critical organs compared to 3DCRT. Larger-scale trials with longer follow-up periods are needed to corroborate these findings and confirm IMRT's efficacy in cervical cancer treatments.
METHODS: We performed a retrospective analysis of 30 patients who received IMRT with weekly cisplatin-based medication. Corresponding 3DCRT plans were generated for comparison. Dosimetric parameters for Planning Target Volume (PTV) and Organs at Risk (OARs) were evaluated. Patients were immobilized in a supine position for simulation, according to conventional protocols.
RESULTS: PTV coverage was similar between IMRT and 3D-CRT groups. However, IMRT showed significantly improved dosimetric outcomes for OARs, including the bladder, rectum, bowel, and bone marrow. IMRT reduced doses to critical organs while maintaining comparable PTV coverage.
CONCLUSION: Patients undergoing IMRT experienced reduced doses to critical organs compared to 3DCRT. Larger-scale trials with longer follow-up periods are needed to corroborate these findings and confirm IMRT's efficacy in cervical cancer treatments.