International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Hepatitis B virus (HBV) DNA is present as both cccDNA and integrated forms in kidney tissues of HBV surface antigen-negative patients with renal cell carcinoma.
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Lombardo Daniele, Rossanese Marta, Musolino Cristina, Giosa Domenico, Bonomo Andrea, Raffa Giuseppina, Chines Valeria, Caminiti Giuseppe, Mucciardi Giuseppe, Chiappetta Michele, Saitta Carlo, Martini Maurizio, Ieni Antonio, Ficarra Vincenzo, Raimondo Giovanni, Pollicino Teresa
Аннотация
OBJECTIVES: This prospective study aimed to (1) determine the intrarenal prevalence of hepatitis B virus (HBV) DNA in HBV surface antigen (HBsAg) negative patients with renal cell carcinoma (RCC), and (2) characterize its molecular forms, including cccDNA and integrated sequences.
METHODS: Renal tissues from 83 consecutive HBsAg-negative patients who underwent nephrectomy for RCC (n = 54) or for nonmalignant disease (control group, n = 29) were tested by highly sensitive PCR for total HBV DNA, cccDNA, and viral RNA, and subjected to high-throughput HBV DNA integration sequencing. Among RCC cases, 36/54 had clear cell RCC (ccRCC), and 18/54 had papillary or chromophobe RCC.
RESULTS: HBV DNA was detected in 35.2% (19/54) of RCC cases vs 3.4% (1/29) of controls (P = 0.001). Among RCC subtypes, HBV DNA prevalence was 25% (9/36) in ccRCC vs 55.6% (10/18) in non-ccRCC (papillary or chromophobe) (P = 0.03). Both cccDNA and integrated HBV sequences were present in RCC tissues harboring viral DNA.
CONCLUSION: Intrarenal presence of HBV DNA is a frequently occurring event strongly associated with RCC, suggesting a potential direct role of HBV in renal carcinogenesis.
METHODS: Renal tissues from 83 consecutive HBsAg-negative patients who underwent nephrectomy for RCC (n = 54) or for nonmalignant disease (control group, n = 29) were tested by highly sensitive PCR for total HBV DNA, cccDNA, and viral RNA, and subjected to high-throughput HBV DNA integration sequencing. Among RCC cases, 36/54 had clear cell RCC (ccRCC), and 18/54 had papillary or chromophobe RCC.
RESULTS: HBV DNA was detected in 35.2% (19/54) of RCC cases vs 3.4% (1/29) of controls (P = 0.001). Among RCC subtypes, HBV DNA prevalence was 25% (9/36) in ccRCC vs 55.6% (10/18) in non-ccRCC (papillary or chromophobe) (P = 0.03). Both cccDNA and integrated HBV sequences were present in RCC tissues harboring viral DNA.
CONCLUSION: Intrarenal presence of HBV DNA is a frequently occurring event strongly associated with RCC, suggesting a potential direct role of HBV in renal carcinogenesis.