Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3).

INTRODUCTION AND

OBJECTIVE

The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3).

MATERIAL AND

METHODS

NK cell and T reg activity in the study patient were analysed using flow cytometry.

RESULTS

Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome.

CONCLUSIONS

Although vulvar cancer may influence immune cell activity, this issue merits further study.