Annals of nuclear medicine · 2026
Straightforward PET phantom preparation using 68Gallium diluted with acid.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yamao Tensho, Miwa Kenta, Hasegawa Koki, Miyaji Noriaki, Akiya Naochika, Wachi Kaito, Ukon Naoyuki, Joho Taiki, Shiga Tohru, Ito Hiroshi
Аннотация
OBJECTIVE: The present study aimed to establish a user-friendly practical way to prepare phantoms for routine quantitative 68Gallium (Ga) PET.
METHODS: We produced gallium ions in 0.05 M HCl from a 68Ge/68Ga generator and prepared a phantom in five ways. We directly diluted [68Ga]Ga3+ in water (i), neutralized [68 Ga]Ga3+ in NaOH then diluted it with water (ii), labeled prostate-specific membrane antigen (PSMA)-617 with [68Ga]Ga3+ then added it to water (iii), and directly added [68Ga]Ga3+ to 0.05 M HCl (iv) and 0.1 M citric acid (v). A cylindrical phantom was scanned for 60 min in list mode, and images were reconstructed into consecutive 5-min frames. Temporal changes in spatial uniformity and image noise were evaluated based on the standard deviations (SD) of inter-ROI differences, coefficients of variation (CV), SUVmean, and the fraction of pixels outside the SUV range of 0.95-1.05.
RESULTS: The visible distribution of activity in the phantom prepared using method (ii) was not uniform with peripheral accumulation, and spatial uniformity progressively deteriorated over time. The SD increased from 0.0206 to 0.0361 at 5 and 60 min, respectively. In contrast, the phantoms prepared using the other four methods yielded visually homogeneous images and the methods (iii), (iv), and (v) maintained relatively stable SDs throughout image acquisition. The CV increased modestly over time under all conditions, and was consistent with decreasing count statistics, whereas SUVmean remained stable with only small deviations from unity. Pixel-wise analysis showed higher fractions of pixels outside SUV 0.95-1.05 for methods (i) and (ii).
CONCLUSIONS: Diluting [68Ga]Ga3+ with 0.05 M HCl or 0.1 M citric acid enabled reliable preparation of a uniform phantom with spatial uniformity comparable to that of radiolabeling. Direct dilution in water showed no apparent peripheral accumulation on visual assessment, but quantitative analyses suggested less stable uniformity than acidic dilution. These approaches are practical for quality assurance and cross-calibration in quantitative 68Ga PET.
METHODS: We produced gallium ions in 0.05 M HCl from a 68Ge/68Ga generator and prepared a phantom in five ways. We directly diluted [68Ga]Ga3+ in water (i), neutralized [68 Ga]Ga3+ in NaOH then diluted it with water (ii), labeled prostate-specific membrane antigen (PSMA)-617 with [68Ga]Ga3+ then added it to water (iii), and directly added [68Ga]Ga3+ to 0.05 M HCl (iv) and 0.1 M citric acid (v). A cylindrical phantom was scanned for 60 min in list mode, and images were reconstructed into consecutive 5-min frames. Temporal changes in spatial uniformity and image noise were evaluated based on the standard deviations (SD) of inter-ROI differences, coefficients of variation (CV), SUVmean, and the fraction of pixels outside the SUV range of 0.95-1.05.
RESULTS: The visible distribution of activity in the phantom prepared using method (ii) was not uniform with peripheral accumulation, and spatial uniformity progressively deteriorated over time. The SD increased from 0.0206 to 0.0361 at 5 and 60 min, respectively. In contrast, the phantoms prepared using the other four methods yielded visually homogeneous images and the methods (iii), (iv), and (v) maintained relatively stable SDs throughout image acquisition. The CV increased modestly over time under all conditions, and was consistent with decreasing count statistics, whereas SUVmean remained stable with only small deviations from unity. Pixel-wise analysis showed higher fractions of pixels outside SUV 0.95-1.05 for methods (i) and (ii).
CONCLUSIONS: Diluting [68Ga]Ga3+ with 0.05 M HCl or 0.1 M citric acid enabled reliable preparation of a uniform phantom with spatial uniformity comparable to that of radiolabeling. Direct dilution in water showed no apparent peripheral accumulation on visual assessment, but quantitative analyses suggested less stable uniformity than acidic dilution. These approaches are practical for quality assurance and cross-calibration in quantitative 68Ga PET.