Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025
Clinicopathological Analysis and Survival Outcomes of Radiation-Induced Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Moura Anne Evelyn Oliveira, Rodrigues-Fernandes Carla Isabelly, Normando Ana Gabriela Costa, Farias Danielle Machado, Lopes Márcio Ajudarte, Vargas Pablo Agustin, Santos-Silva Alan Roger, de Abreu Alves Fábio, Kowalski Luiz Paulo, da Cruz Perez Danyel Elias
Аннотация
BACKGROUND: Radiotherapy-induced malignancies are well-documented, but the clinicopathological profile and prognostic factors of radiation-induced oral squamous cell carcinoma (R-OSCC) remain unclear.
METHODS: The present review was conducted in accordance with the PRISMA guidelines and has been registered in the PROSPERO (registration number CRD42024560015). A comprehensive search was performed across electronic databases and gray literature sources. The risk of bias was assessed using the JBI tool. Meta-analysis was performed with Review Manager 5.4.
RESULTS: Five cohort studies were included (n = 310), with four pooled in a meta-analysis. R-OSCC was significantly associated with tongue tumors (p = 0.007) and early clinical stages (p < 0.0001). Negative perineural invasion was linked to sporadic OSCC (p = 0.0008). Smoking (p = 0.0008) and radiotherapy (RT) history (p < 0.00001) were associated with decreased overall survival (OS), while RT history also reduced disease-specific survival (DSS) in R-OSCC patients (p = 0.006).
CONCLUSIONS: R-OSCC predominantly affects the tongue, is diagnosed in early stages, and the history of RT is associated with reduced OS and DSS.
METHODS: The present review was conducted in accordance with the PRISMA guidelines and has been registered in the PROSPERO (registration number CRD42024560015). A comprehensive search was performed across electronic databases and gray literature sources. The risk of bias was assessed using the JBI tool. Meta-analysis was performed with Review Manager 5.4.
RESULTS: Five cohort studies were included (n = 310), with four pooled in a meta-analysis. R-OSCC was significantly associated with tongue tumors (p = 0.007) and early clinical stages (p < 0.0001). Negative perineural invasion was linked to sporadic OSCC (p = 0.0008). Smoking (p = 0.0008) and radiotherapy (RT) history (p < 0.00001) were associated with decreased overall survival (OS), while RT history also reduced disease-specific survival (DSS) in R-OSCC patients (p = 0.006).
CONCLUSIONS: R-OSCC predominantly affects the tongue, is diagnosed in early stages, and the history of RT is associated with reduced OS and DSS.