Journal of periodontal research · 2010
Diabetes mellitus-associated periodontitis: differences between type 1 and type 2 diabetes mellitus.
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Aspriello S D, Zizzi A, Tirabassi G, Buldreghini E, Biscotti T, Faloia E, Stramazzotti D, Boscaro M, Piemontese M
Аннотация
BACKGROUND AND OBJECTIVE: Although many studies have appeared about diabetes mellitus-associated periodontitis, few have compared periodontitis inflammatory markers between type 1 (T1DM) and type 2 diabetes mellitus (T2DM), and information regarding this issue is scarce and contradictory. We evaluated the levels of plasma C-reactive protein and of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in gingival crevicular fluid in two groups of subjects affected by T1DM and T2DM, in order to identify possible differences between the two classes in the inflammatory mechanisms of diabetes mellitus-associated periodontitis.
MATERIAL AND METHODS: Plasma C-reactive protein and gingival crevicular fluid IL-1β, IL-6 and TNF-α were measured in periodontitis patients affected by type 1 (P-T1DM, n = 24) and type 2 diabetes mellitus (P-T2DM, n = 24).
RESULTS: Gingival crevicular fluid levels of IL-1β and TNF-α in P-T1DM subjects were significantly higher than in P-T2DM subjects. In P-T1DM subjects, we found significant negative correlations between the duration of diabetes mellitus and IL-1β and between the duration of diabetes mellitus and TNF-α.
CONCLUSION: This study shows that IL-1β and TNF-α levels in periodontitis patients with T1DM are affected by the duration of diabetes mellitus.
MATERIAL AND METHODS: Plasma C-reactive protein and gingival crevicular fluid IL-1β, IL-6 and TNF-α were measured in periodontitis patients affected by type 1 (P-T1DM, n = 24) and type 2 diabetes mellitus (P-T2DM, n = 24).
RESULTS: Gingival crevicular fluid levels of IL-1β and TNF-α in P-T1DM subjects were significantly higher than in P-T2DM subjects. In P-T1DM subjects, we found significant negative correlations between the duration of diabetes mellitus and IL-1β and between the duration of diabetes mellitus and TNF-α.
CONCLUSION: This study shows that IL-1β and TNF-α levels in periodontitis patients with T1DM are affected by the duration of diabetes mellitus.
Предметные рубрики MeSH
AdultAgedAlveolar Bone LossAntihypertensive AgentsC-Reactive ProteinChronic PeriodontitisDental Plaque IndexDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Gingival Crevicular FluidGingival HemorrhageHumansHypoglycemic AgentsInflammation MediatorsInsulinInterleukin-1betaInterleukin-6Middle AgedPeriodontal Attachment LossPeriodontal IndexPeriodontal PocketTime FactorsTumor Necrosis Factor-alpha